细胞凋亡是由核的形态变化所决定的,包括染色质浓缩和核碎裂。该基因编码一种核蛋白,在caspase-3激活后诱导凋亡染色质浓缩,而不诱导dna断裂。该蛋白还被证明是一种剪接依赖性多蛋白外显子连接复合体(EJC)的组成部分,其在mRNAs的剪接连接处沉积,是mRNA前剪接的结果因此,它可能参与与剪接相关的mrna代谢。另外,编码不同亚型的剪接转录变体已经被描述为该基因[由RefSeq提供,2011年10月]
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

基因名:ACIN1
别名:ACN,ACINUS,fSAP152
基因ID:22985
Chromosome:
(GRCh37)
14 Start: 23527773 End: 23564823 Strand: 
信号通路:  
ACIN1 基因突变与药物

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