肾上腺素能受体(α1、α2、β1和β2亚型)是鸟嘌呤核苷酸结合调节蛋白偶联受体的一个原型家族,介导肾上腺素和神经递质去甲肾上腺素的生理效应。β1肾上腺素受体主要位于心脏。该基因的特异性多态性已被证明影响静息心率,并可能与心力衰竭有关。[由RefSeq提供,2019年9月]
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]
基因名: | ADRB1 |
别名: | RHR,B1AR,FNSS2,ADRB1R,BETA1AR |
基因ID: | 153 |
Chromosome: (GRCh37) | 10 Start: 115803806 End: 115806667 Strand: |
信号通路: |