该基因编码一个多域蛋白,参与胚胎发育过程中细胞连接的信号和组织该基因与t(6;11)(q27;q23)易位的急性髓系白血病(americ myeloid leukemia,all-1)基因融合。另外,编码不同亚型的剪接转录变体已经被描述用于该基因,然而,并不是所有的都已经被完全描述出来了。[由RefSeq提供,2011年5月]
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]

基因名:AFDN
别名:AF6,MLLT4,MLL-AF6,l-afadin
基因ID:4301
Chromosome:
(GRCh37)
6 Start: 168227602 End: 168372703 Strand: 
信号通路:  
AFDN 基因突变与药物

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