该基因编码Argonaute家族的一个成员,在RNA干扰中起作用。编码的蛋白质是高度碱性的,包含PAZ结构域和PIWI结构域,可能在短干扰RNA介导的基因沉默中发挥作用该基因位于1号染色体上,由Argonaute 4和真核翻译起始因子2C,1等家族成员串联而成。已鉴定出两个编码不同亚型的转录变体[由RefSeq提供,2008年7月]
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

基因名:AGO3
别名:EIF2C3
基因ID:192669
Chromosome:
(GRCh37)
1 Start: 36396364 End: 36522360 Strand: 
信号通路:  
AGO3 基因突变与药物

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