该基因编码的蛋白是细胞周期蛋白依赖性蛋白激酶（CDK）家族的成员cdk家族成员与酿酒酵母cdc28和裂殖酵母pombe cdc2的基因产物高度相似，是细胞周期进程的重要调控因子。该基因被鉴定为白血病患者5q染色体缺失的基因这种缺失可能是骨髓生成障碍的一个重要决定因素选择性剪接导致编码不同亚型的多个转录变体[由RefSeq提供，2008年7月]
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]