该基因是尾相关同源盒转录因子基因家族的成员。编码蛋白是参与细胞生长和分化的肠道特异性基因的主要调节因子。这种蛋白也在肠道的早期胚胎发育中起作用。这种基因的异常表达与肠道炎症和肿瘤发生有关。
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.