该基因编码的蛋白质通常存在于内质网（er）的膜中。然而，在对内质网的胁迫下，编码的蛋白质被裂解，释放的细胞质转录因子结构域转移到细胞核。在那里，它通过与box-b元素结合来激活靶基因的转录。[由RefSeq提供，2013年6月]
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]