这个基因编码肉碱/胆碱乙酰转移酶家族的一个成员。编码的蛋白质将4,8-二甲基壬酰基-CoA转化为相应的肉碱酯这种酯交换反应发生在过氧化物酶体中,是将长链酰基-CoA分子从过氧化物酶体转运到细胞质和线粒体所必需的。因此,蛋白质在脂质代谢和脂肪酸β氧化中起作用。已经描述了选择性剪接的转录变体。[由refseq提供,2009年1月]
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
基因名: | CROT |
别名: | COT |
基因ID: | 54677 |
Chromosome: (GRCh37) | 7 Start: 86974951 End: 87029112 Strand: |
信号通路: |