CTIF是CBP80(NCBP1;MIM 600469)/CBP20(NCBP2;MIM 605133)翻译起始复合物的一个组成部分,该复合物与新生mRNA的帽端共转录结合cbp80/cbp20复合物参与同时编辑和翻译步骤,该步骤识别mrnas中的过早终止密码子(ptc),并将含有mrnas的ptc导向无义介导的衰变(nmd)。在没有PTCs的mRNA上,CBP80/CBP20复合物被细胞质mRNA cap结合蛋白取代,包括EIF4G(MIM 600495),mRNA的稳态翻译在细胞质中恢复(Kim等人,2009【PubMed 19648179】。【OMIM提供,2009年12月】
CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

基因名:CTIF
别名:Gm672,KIAA0427
基因ID:9811
Chromosome:
(GRCh37)
18 Start: 46065427 End: 46389588 Strand: 
信号通路:  
CTIF 基因突变与药物

相关基因检测