这个基因编码的蛋白质是组蛋白甲基转移酶,它使组蛋白h3的赖氨酸-79甲基化。它对游离核心组蛋白不起作用,但对核小体显示出显著的组蛋白甲基转移酶活性。[由RefSeq提供,2011年8月]
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

基因名:DOT1L
别名:DOT1,KMT4
基因ID:84444
Chromosome:
(GRCh37)
19 Start: 2164148 End: 2232577 Strand: 
信号通路: 基因组不稳定 
DOT1L 基因突变与药物

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