EME2与MUS81（MIM 606591）形成异二聚体，在DNA修复中作为XPF（MIM 278760）型皮瓣/叉形内切酶发挥作用（Ciccia等人，2007【PubMed 17289582】。【OMIM提供，2008年3月】
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]