这个基因编码三个相关的丝素基因之一,特别是γ-丝素。这些丝素蛋白将肌动蛋白丝交联成皮质细胞质中的正交网络,并参与肌动蛋白细胞骨架膜蛋白的锚定。在丝状蛋白中存在三个功能域:N-末端丝状肌动蛋白结合结构域、C-末端自结合结构域和膜糖蛋白结合结构域。已经发现了两个编码不同亚型的转录变体。[由RefSeq提供,2008年7月]
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

基因名:FLNC
别名:ABPA,ABPL,FLN2,MFM5,MPD4,RCM5,CMH26,ABP-280,ABP280A
基因ID:2318
Chromosome:
(GRCh37)
7 Start: 128470436 End: 128499328 Strand: 
信号通路:  
FLNC 基因突变与药物

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