这个基因编码DNA结合蛋白叉头类的一个成员这些肝细胞核因子是肝特异性基因如白蛋白和甲状腺素的转录激活因子，它们也与染色质相互作用。相似的家族成员在小鼠的代谢调节和胰腺、肝脏的分化中也有作用这个基因与年轻人的成年期糖尿病的零星病例有关编码不同亚型的转录变体已经被鉴定为该基因。[由RefSeq提供，2008年10月]
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]