这个基因是卷毛基因家族的一员该家族成员编码7-跨膜结构域蛋白，它们是无翅型MMTV整合位点信号蛋白家族的受体大多数皱褶受体与β-连环蛋白典型信号通路偶联。利用阵列分析，这一无内含子基因在两例原发性结肠癌中的表达显著上调。[由RefSeq提供，2008年7月]
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]