组胺是一种普遍存在的信使分子，从肥大细胞、肠嗜铬样细胞和神经元中释放出来。其多种作用由组胺受体h1、h2、h3和h4介导。组胺受体H2属于G蛋白偶联受体家族1它是一种完整的膜蛋白，刺激胃酸分泌它还调节胃肠运动和肠道分泌，被认为参与调节细胞生长和分化。另外，已经发现该基因编码不同亚型的剪接转录变体[由RefSeq提供，2008年8月]
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]