该基因编码的蛋白质是一种转录调节因子和肿瘤抑制因子，是参与先天性和获得性免疫应答的基因激活因子。编码的蛋白质激活参与机体对病毒和细菌反应的基因转录，在细胞增殖、凋亡、免疫反应和DNA损伤反应中发挥作用这种蛋白质抑制其他几个基因的转录。作为一种抑癌剂，它既抑制肿瘤细胞的生长，又刺激对肿瘤细胞的免疫反应。这个基因的缺陷与胃癌、骨髓白血病和肺癌有关[由RefSeq提供，2017年8月]
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]