该基因属于jumonji结构域2（jmjd2）家族。编码的蛋白质是一种三甲基化特异性脱甲基酶，并将特异性三甲基化组蛋白残基转化为二甲基化形式这种酶作用调节基因表达和染色体分离在肿瘤细胞中可发现染色体畸变和该基因表达的变化。选择性剪接导致多个转录变体[由RefSeq提供，2015年1月]
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]