KRT18编码I型中间丝链角蛋白18。角蛋白18及其丝状伴侣角蛋白8可能是中间丝基因家族中最常见的成员。在人体单层上皮组织中表达。这种基因的突变与隐源性肝硬化有关。两个编码相同蛋白质的转录变体被发现用于这个基因。
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.