该基因编码一个属于lats抑癌基因家族的丝氨酸/苏氨酸蛋白激酶。蛋白质在间期、早中期和晚中期定位于中心体。它与中心体蛋白aurora-a和ajuba相互作用,是有丝分裂开始时γ-微管蛋白积累和纺锤体形成所必需的。它还与p53的负调节因子相互作用,并可能与p53形成正反馈回路,对细胞骨架损伤作出反应。此外,它还可以作为雄激素反应基因表达的共同抑制因子。[由RefSeq提供,2008年7月]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

基因名:LATS2
别名:KPM
基因ID:26524
Chromosome:
(GRCh37)
13 Start: 21547175 End: 21635722 Strand: 
信号通路:  
LATS2 基因突变与药物

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