该基因编码丝裂原活化蛋白激酶激酶激酶家族的一个成员编码的蛋白质激活了细胞信号传递中的关键效应器，其中包括c-jun。已经观察到该基因编码多个亚型的选择性剪接转录物。[由RefSeq提供，2012年7月]
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]