这个基因编码胰腺β细胞功能的调节因子。它与小鼠c-jun氨基末端激酶(mapk8)的调节蛋白jip-1高度相似。该蛋白已被证明能阻止MAPK8介导的转录因子激活,并能减少IL-1β和MAP kinase激酶1(MEKK1)诱导的胰腺β细胞凋亡该蛋白也作为葡萄糖转运蛋白GLUT2的DNA结合反式激活因子发挥作用据报道,RE1沉默转录因子(REST)抑制胰岛素分泌β细胞中该基因的表达该基因在2型糖尿病家族中突变,因此被认为是2型糖尿病的易感基因[由RefSeq提供,2011年5月]
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

基因名:MAPK8IP1
别名:IB1,JIP1,JIP-1,PRKM8IP
基因ID:9479
Chromosome:
(GRCh37)
11 Start: 45907047 End: 45928016 Strand: 
信号通路:  
MAPK8IP1 基因突变与药物

相关基因检测