该基因编码一种抗凋亡蛋白,属于bcl-2家族。选择性剪接导致多个转录变体。最长的基因产物(亚型1)通过抑制细胞凋亡来增强细胞存活,而交替剪接的较短的基因产物(亚型2和亚型3)则促进细胞凋亡并诱导死亡。[由RefSeq提供,2010年10月]
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

基因名:MCL1
别名:TM,EAT,MCL1L,MCL1S,Mcl-1,BCL2L3,MCL1-ES,bcl2-L-3,mcl1/EAT
基因ID:4170
Chromosome:
(GRCh37)
1 Start: 150547027 End: 150552214 Strand: 
信号通路: 细胞增殖 
MCL1 基因突变与药物

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