这个基因编码一个dna错配修复muts家族的成员。该成员是一种减数分裂特异性蛋白质,不参与DNA错配纠正,但在减数分裂I时需要互惠重组和同源染色体的适当分离。该蛋白和msh5形成一个异二聚体,该异二聚体与Holliday连接点及其发育前体特异结合,从而激发adp-atp交换,稳定了减数分裂双链断裂修复过程中亲本染色体间的相互作用。[由RefSeq提供,2011年8月]
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]

基因名:MSH4
别名:
基因ID:4438
Chromosome:
(GRCh37)
1 Start: 76262556 End: 76379581 Strand: 
信号通路:  
MSH4 基因突变与药物

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