该基因编码一种鸟苷三磷酸（GTP）代谢蛋白，参与细胞抗病毒反应该编码蛋白由Ⅰ型和Ⅱ型干扰素诱导，对抗几种不同rna和dna病毒的复制过程。在21号染色体上有一个与此基因相邻的相关基因，在4号染色体上有多个假基因选择性剪接导致多个转录变体[由RefSeq提供，2013年9月]
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]