该基因编码的蛋白是参与细胞周期进程的核蛋白,属于MYB家族转录因子基因编码蛋白在细胞周期的S期被细胞周期蛋白A/cyclin依赖性激酶2磷酸化,具有激活和抑制活性它已被证明能激活细胞分裂周期2、细胞周期蛋白D1和胰岛素样生长因子结合蛋白5基因已经发现了两个编码不同亚型的转录变体。[由RefSeq提供,2013年7月]
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

基因名:MYBL2
别名:BMYB,B-MYB
基因ID:4605
Chromosome:
(GRCh37)
20 Start: 42295659 End: 42345136 Strand: 
信号通路:  
MYBL2 基因突变与药物

相关基因检测