核孔复合体是一个巨大的结构，它横跨核膜，形成一个通道，调节大分子在细胞核和细胞质之间的流动。核孔蛋白是真核细胞核孔复合体的主要成分。该基因编码一种核孔蛋白，定位于孔篮和孔中央门控通道的核入口。编码蛋白是caspase半胱氨酸蛋白酶的一个靶点，在细胞凋亡的程序性死亡中起中心作用。选择性剪接导致编码不同亚型的多个转录变体。[由RefSeq提供，2016年12月]
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]