该基因编码脯氨酰4-羟化酶的β亚单位,脯氨酰4-羟化酶是一种非常丰富的多功能酶,属于蛋白质二硫化物异构酶家族当以包含两个α和两个β亚单位的四聚体存在时,这种酶参与前胶原中脯氨酰残基的羟基化这种酶也是二硫键异构酶,含有两个硫氧还蛋白域,催化二硫键的形成、断裂和重排。其他已知功能包括其作为伴侣的能力,其以浓度依赖性方式抑制错折叠蛋白的聚集,其结合甲状腺激素的能力,其在S-亚硝基硫醇结合的一氧化氮的流入和流出中的作用,以及其作为微粒体甘油三酯转移蛋白复合物的亚基的功能。[由RefSeq提供,2008年7月]
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

基因名:P4HB
别名:DSI,GIT,PDI,PHDB,PDIA1,PO4DB,PO4HB,PROHB,CLCRP1,ERBA2L,P4Hbeta
基因ID:5034
Chromosome:
(GRCh37)
17 Start: 79801034 End: 79818566 Strand: 
信号通路:  
P4HB 基因突变与药物

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