这个基因编码一种多聚(a)结合蛋白。蛋白质在细胞核和细胞质之间穿梭,通过rna识别基序与真核信使rna的3'聚(a)尾结合。该蛋白与poly(A)的结合促进了核糖体的募集和翻译起始;poly(A)缩短也是mRNA衰变的第一步该基因是一个小基因家族的一部分,包括三个蛋白质编码基因和几个假基因
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

基因名:PABPC1
别名:PAB1,PABP,PABP1,PABPC2,PABPL1
基因ID:26986
Chromosome:
(GRCh37)
8 Start: 101715144 End: 101734969 Strand: 
信号通路:  
PABPC1 基因突变与药物

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