这个基因编码一种属于3'5'-环核苷酸磷酸二酯酶家族的酶。这个家族的成员催化环核苷酸、环磷酸腺苷和环磷酸鸟苷水解成相应的核苷5'-单磷酸该基因编码的酶调节血管平滑肌细胞的增殖、迁移和内膜增生这种酶还通过调节生长因子受体(如PDGF受体β)的稳定性在病理性血管重塑中发挥作用[由RefSeq提供,2016年7月]
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

基因名:PDE1C
别名:Hcam3,DFNA74,hCam-3,cam-PDE1C
基因ID:5137
Chromosome:
(GRCh37)
7 Start: 31791666 End: 32339016 Strand: 
信号通路:  
PDE1C 基因突变与药物

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