该基因编码的蛋白属于磷酸肌醇3激酶(pi3k)家族。pi3激酶在参与细胞增殖、癌基因转化、细胞存活、细胞迁移和细胞内蛋白质转运的信号传导途径中发挥作用。该蛋白包含一个脂质激酶催化结构域和一个C末端C2结构域,这是II类PI3激酶的特征。C2结构域作为钙依赖性磷脂结合基序,介导蛋白质向膜的转运,也可能介导蛋白质-蛋白质的相互作用。该蛋白的pi3激酶活性对抑制剂wortmanin的低纳摩尔水平敏感。该蛋白的c2结构域与磷脂结合,而不是与ca2+结合,这表明该酶的功能可能与钙无关。[由RefSeq提供,2008年7月]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

基因名:PIK3C2B
别名:C2-PI3K
基因ID:5287
Chromosome:
(GRCh37)
1 Start: 204391756 End: 204463943 Strand: 
信号通路: 细胞增殖  免疫相关  炎症相关  侵袭和转移  血管生成  能量代谢  肿瘤干细胞 
PIK3C2B 基因突变与药物

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