该基因编码的蛋白属于磷酸肌醇3激酶(pi3k)家族。pi3激酶在参与细胞增殖、癌基因转化、细胞存活、细胞迁移和细胞内蛋白质转运的信号传导途径中发挥作用。该蛋白包含一个脂质激酶催化结构域和一个C末端C2结构域,这是II类PI3激酶的特征。C2结构域作为钙依赖性磷脂结合基序,介导蛋白质向膜的转运,也可能介导蛋白质-蛋白质的相互作用。这个基因可能在一些疾病中起作用,包括II型糖尿病。选择性剪接导致多个转录变体。[由RefSeq提供,2014年1月]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

基因名:PIK3C2G
别名:PI3K-C2GAMMA,PI3K-C2-gamma
基因ID:5288
Chromosome:
(GRCh37)
12 Start: 18395912 End: 18801352 Strand: 
信号通路:  
PIK3C2G 基因突变与药物

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