该基因编码dna聚合酶delta的66kda亚单位。DNA聚合酶delta具有聚合酶和3'到5'外切酶活性，在DNA复制和修复中起着关键作用编码蛋白通过与其它亚单位的相互作用和加工性辅因子增殖细胞核抗原（pcna）的作用，在调控dna聚合酶δ的活性中发挥作用。另外，已经观察到该基因的剪接转录变体[由RefSeq提供，2012年3月]
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]