该基因编码丝氨酸/苏氨酸蛋白激酶蛋白激酶c(pkc)家族的一个成员。pkc家族至少由8个成员组成,它们是差异表达的,参与多种细胞过程。这种蛋白激酶不依赖钙和磷脂。它不被佛波酯或甘油二酯激活。这种激酶可以通过与小gtpase rab2的直接相互作用被募集到囊泡管簇(vtcs),在那里这种激酶磷酸化甘油醛-3-磷酸脱氢酶(gapd/gapdh),并在早期分泌途径中的微管动力学中发挥作用。这种激酶被认为是bcl-abl介导的抗药物诱导凋亡所必需的,因此可以保护白血病细胞免受药物诱导的凋亡。在x染色体上有一个外显子假基因。
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

基因名:PRKCI
别名:PKCI,DXS1179E,nPKC-iota
基因ID:5584
Chromosome:
(GRCh37)
3 Start: 169940220 End: 170023770 Strand: 
信号通路: 细胞增殖  肿瘤干细胞 
PRKCI 基因突变与药物

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