该基因编码丝氨酸蛋白酶的肽酶s1或糜蛋白酶家族的一个成员。编码的前蛋白通过蛋白质水解产生轻链和重链,通过二硫键结合形成异二聚体酶。这种酶在前列腺上皮中高度表达,是在精液中发现的几种蛋白水解酶之一。这种蛋白酶具有胰蛋白酶样底物特异性,在赖氨酸或精氨酸残基的羧基末端切割蛋白质底物。编码的蛋白酶部分介导上皮钠通道(钠平衡的调节者)的蛋白水解酶激活,并可能在上皮屏障形成中发挥作用。[由RefSeq提供,2016年2月]
This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

基因名:PRSS8
别名:CAP1,PROSTASIN
基因ID:5652
Chromosome:
(GRCh37)
16 Start: 31142754 End: 31147151 Strand: 
信号通路: 细胞增殖 
PRSS8 基因突变与药物

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