蛋白酶体是一种多催化蛋白酶复合物,具有高度有序的环状20s核结构。核心结构由4环28个不完全相同的亚基组成;2环由7个α亚基组成,2环由7个β亚基组成蛋白酶体以高浓度分布于真核细胞中,在非溶酶体途径中以ATP/泛素依赖的方式裂解肽一种修饰的蛋白酶体,即免疫蛋白酶体,其基本功能是处理一类MHC肽这个基因编码蛋白酶体b型家族的一个成员,也被称为t1b家族,即20s核心β亚单位。已发现该基因的多个选择性剪接转录变体编码不同的亚型。[由RefSeq提供,2010年12月]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

  1. 基因通路图
基因名:PSMB2
别名:HC7-I
基因ID:5690
Chromosome:
(GRCh37)
1 Start: 36040259 End: 36107445 Strand: 
信号通路:  
PSMB2 基因突变与药物

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