双侧对称的神经系统有特殊的中线结构,在两个镜像的一半之间建立一个分割。一些轴突投射到中线并穿过中线,以响应中线发出的长程趋化物。该基因的产物是免疫球蛋白基因超家族的一员,编码一种完整的膜蛋白,在轴突引导和神经元前体细胞迁移中发挥作用这种受体被slit家族蛋白激活,对发育中的脑胶质瘤细胞的诱导产生排斥作用。一个相关基因位于3号染色体的相邻区域已发现该基因编码不同亚型的多个转录变体。〔RefSeq,2009〕
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

基因名:ROBO1
别名:SAX3,DUTT1
基因ID:6091
Chromosome:
(GRCh37)
3 Start: 78646388 End: 79817059 Strand: 
信号通路:  
ROBO1 基因突变与药物

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