这个基因编码包含转录因子家族的runt结构域的一个成员。这种蛋白质的一个异二聚体和一个β亚单位形成一个复合物,结合在许多增强子和启动子中发现的核心dna序列5'-pygpyggt-3',可以激活或抑制转录。它还与其他转录因子相互作用。它作为一种抑癌基因,在癌症中经常被删除或转录沉默。选择性剪接导致多个转录变体。[由RefSeq提供,2016年3月]
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

基因名:RUNX3
别名:AML2,CBFA3,PEBP2aC
基因ID:864
Chromosome:
(GRCh37)
1 Start: 25226002 End: 25291648 Strand: 
信号通路:  
RUNX3 基因突变与药物

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