该基因编码应激诱导蛋白的sestrin家族的一个成员。编码的蛋白降低了racα-丝氨酸/苏氨酸蛋白激酶(akt)下游激活ras和foxo转录因子诱导的细胞内活性氧的水平。该蛋白是正常调节血糖、胰岛素抵抗所必需的,在肥胖中起着脂质储存的作用选择性剪接导致多个转录变体[由RefSeq提供,2012年10月]
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

基因名:SESN3
别名:SEST3
基因ID:143686
Chromosome:
(GRCh37)
11 Start: 94898677 End: 94965705 Strand: 
信号通路:  
SESN3 基因突变与药物

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