这个基因编码的蛋白质属于尿素转运体家族。在哺乳动物细胞中，尿素是氮分解代谢的主要终产物，在尿液浓缩机制中起着重要作用这种蛋白在肾的内髓质中表达，并介导快速的尿素经髓转运穿过内髓质集合管。另外，已经发现该基因的剪接转录变体。[由RefSeq提供，2011年9月]
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]