这个基因编码的蛋白质是基因组稳定性的重要调节因子该蛋白代表SLX1-SLX4结构特异性核酸内切酶的催化亚单位,它可以解析修复和重组过程中形成的DNA二级结构由于节段性重复,该基因的两个相同拷贝位于16号染色体的p臂上;该记录代表更多的着丝粒拷贝。选择性剪接导致多个转录变体该基因与下游SULT1A3(硫转移酶家族,胞质,1A,苯酚偏好,成员3)基因之间也存在读写转录[由RefSeq提供,2010年11月]
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]

基因名:SLX1A
别名:GIYD1
基因ID:548593
Chromosome:
(GRCh37)
16 Start: 30205164 End: 30208887 Strand: 
信号通路:  
SLX1A 基因突变与药物

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