姐妹染色单体的适当结合是细胞分裂过程中染色体正确分离的先决条件。黏着素多蛋白复合物是姐妹染色单体黏合所必需的。该复合物部分由两种染色体（smc）蛋白结构维持组成，smc3和smc1b或由该基因编码的蛋白。在有丝分裂前，大多数黏着蛋白复合物与染色体分离，但在动粒处的复合物仍然存在因此，编码蛋白被认为是功能性动粒的重要组成部分。此外，该蛋白与brca1相互作用并被atm磷酸化，这表明该蛋白在dna修复中具有潜在的作用。该基因属于SMC基因家族，位于X染色体上逃避X失活的区域该基因突变导致Cornelia-de-Lange综合征。选择性剪接导致编码不同亚型的多个转录变体[由RefSeq提供，2013年7月]
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]