该基因编码c2h2型锌指转录因子蜗牛家族的一个成员。编码蛋白作为一种转录抑制因子,与e-box基序结合,也可能抑制乳腺癌中e-cadherin的转录。该蛋白参与上皮-间质转化,具有抗凋亡活性该基因突变可能与神经管缺陷的孢子状病例有关。[由RefSeq提供,2008年7月]
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

基因名:SNAI2
别名:SLUG,WS2D,SLUGH,SLUGH1,SNAIL2
基因ID:6591
Chromosome:
(GRCh37)
8 Start: 49830236 End: 49833999 Strand: 
信号通路:  
SNAI2 基因突变与药物

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