这个基因编码一个RNA结合蛋白TET家族的成员所编码的蛋白质作为一个多亚单位转录起始因子tfiid复合物的不同亚组分在rna聚合酶ii基因转录中发挥作用。涉及该基因的易位在急性白血病和骨外黏液样软骨肉瘤中起作用，该基因突变可能在肌萎缩性侧索硬化中起作用。另外，已经观察到该基因编码多个亚型的剪接转录变体[由RefSeq提供，2012年5月]
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]