该基因编码磷酸肌醇3激酶相关激酶(pikk)家族的一个大的多域蛋白。编码蛋白是许多组蛋白乙酰转移酶(hat)复合物的共同组成部分,在转录和dna修复中起着重要作用。该基因的解除调控可能在多种类型的癌症中起作用,包括多形性胶质母细胞瘤。另外,已经观察到该基因编码多个亚型的剪接转录变体。[由RefSeq提供,2011年9月]
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

基因名:TRRAP
别名:Tra1,TR-AP,DEDDFA,PAF400,STAF40,PAF350/400
基因ID:8295
Chromosome:
(GRCh37)
7 Start: 98476113 End: 98610866 Strand: 
信号通路:  
TRRAP 基因突变与药物

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