丁艳华,女,医学博士,主任医师,教授,硕士生导师。现就职于吉林大学第一医院。任吉林大学第一医院I期药物临床试验病房主任。
主要研究方向:
1、干扰素-γ;s基因变异及其表达水平与丙型肝炎病毒感染转归;
2、临床流行病学遗传药理学(肝病及心血管疾病药物代谢酶、转运体基因多态性、血药浓度与疗效评价);
3、新药耐受性及药代动力学。
承担课题:
1、负责国家自然科学基金面上项目3项(药物转运、代谢及药物作用点相关遗传变异因素对冠状动脉支架术人群抗血小板治疗结局影响的前瞻性随访研究(81473037) 85万元;干扰素-γs基因变异及其表达水平与丙型肝炎病毒感染转归(81172726) 65万元;原发性高血压靶器官损伤与HLA-DQ7、DR11、HLA-B51基因多态性关系的研究(30872174) 35万元。
2、参与国家科技重大专项课题(肝脏疾病国际规范临床试验技术平台建设)1项 670万元
主要SCI文章:
1.Xiaojiao Li, Chang Liu, Yanhua Ding*,et al.Pharmacokinetics, pharmacodynamics and tolerability of single- and multiple-doses of trandolapril, an effective angiotensin-converting enzyme inhibitor, in healthy Chinese subjects[J].European Journal of Drug Metabolism and Pharmacokinetics. In press.
2.H Chen, Q Zhang, X Li, YH Ding*,et al.Single- and Multiple-Dose Pharmacokinetics and Tolerability of Limaprost in Healthy Chinese Subjects[J].Clinical Drug Investigation, (2015) 35:151–157.
3.H Zhang, H Chen, YH Ding*,et al.Pharmacokinetics and safety profiles of novel diethylstilbestrol orally dissolving film in comparison with diethylstilbestrol capsules in healthy Chinese male subjects[J]. International Journal of Clinical Pharmacology and Therapeutics, 2014 ,52(5):407-415.
4.Li X, Liu B, Sun Y, YH Ding*,et al. Single-Dose Pharmacokinetic Properties, Bioavailability, and Tolerability of Two Lamivudine 100-mg Tablet Formulations: A Randomized Crossover Study in Healthy Chinese Male Subjects[J]. Clinical therapeutics, 2013, 35(10): 1546-1556.
5.Ding Y, Zhang H, Li Y, et al. Inhibition of HCV 5′-NTR and Core Expression by a Small Hairpin RNA Delivered by a Histone Gene Carrier, HPhA[J]. International journal of medical sciences, 2013, 10(8): 957.
6.QM Li, B Li, YF Sun, H Zhang, XL Yang, LW Cai, H Chen, YH Ding* and J Jiang. Association of HLA-DRB1 Single Nucleotide Polymorphisms with Left Ventricular Remodelling in Elderly Patients with Essential Hypertension. The Journal of International Medical Research. 2012; 40: 2152-2159.
7.Jia Z, Ding Y, Tian S, et al. Test of IL28B polymorphisms in chronic hepatitis C patients treated with PegIFN and ribavirin depends on HCV genotypes: results from a meta-analysis[J]. PloS one, 2012, 7(9): e45698.
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